Cancer CHAIR: Sirio Dupont
14:30-15:00	Welcome Addresses Rosario Rizzuto · Rector of the University of Padua Valeria Poli · SIBBM President Sirio Dupont · Organising Committee of the SIBBM Seminar 2021
15:00-15:45	AIRC Keynote Lecture Karen Vousden, The Francis Crick Institute, London, UK Dietary modulation and cancer therapy
15:45-16:00	Giovannina Barisciano, University of Sannio, Benevento, Italy The miR-27a/FOXJ3 axis negatively regulates mitochondrial homeostasis in colorectal cancer cells
16:00-16:15	Marco Sciacovelli, University of Cambridge, UK Nitrogen partitioning between branched-chain amino acids and urea cycle sustains renal cancer progression
16:15-16:30	Break (15')
16:30-17:00	Ilaria Elia, Harvard Medical School, Boston, MA, USA Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells
	Stem Cells CHAIR:  Graziano Martello
17:00-17:15	Chiara Priami, European Institute of Oncology, Milan, Italy P66Shc-dependent asymmetric division of stem cells leads to aging of the mammary gland
17:15-17:45	EMBL Lecture Micheal Teitell, UCLA, Los Angeles, CA, USA Mitochondrial Transfer and Cell Fate Transitions
17:45-19:00	Poster session 1

	Epigenetics CHAIRS:  Piero Carninci and Alessandra Montecucco
14:30-15:00	"Riccardo Cortese" Lecture Kathryn Wellen, University of Pennsylvania, Philadelphia, PA, USA Metabolic compartmentalization and chromatin modification
15:00-15:15	Vincenzo Sorrentino, Nestlé Research, Lausanne, Switzerland Trigonelline is a novel NAD+ precursor with anti-aging muscle benefits across species
15:15-15:45	John O’Neill, MRC Laboratory of Molecular Biology, University of Cambridge, UK The mechanism and function of biological rhythms
15:45-16:00	Break (15')
16:00-16:15	Riccardo Betto, University of Padua, Italy Stat3 links the metabolic profile and DNA methylation in murine ESCs
16:15-16:45	Nico Mitro, University of Milan, Italy · sponsored by Giovanni Armenise-Harvard Foundation Zc3h10 dependent control of cellular metabolism
16:45-17:00	Mariella Cuomo, University of Naples “Federico II”, Italy DNA methylation dynamics at genes specific level during brain development and in schizophrenia
17:00-18:00	Science and Society Round table: scientific communication and publishing, an update Cornelius Gross, Scientific Director EMBL, Monterotondo · MODERATOR Sharon Ahmad, Executive Editor Journal of Cell Science George Caputa, Editor Nature and Nature Metabolism Daniel Klimmeck, Editor EMBO Journal Rosalind Mott, Editor Cell Metabolism
18:00-19:00	Poster session 2

	Cell Stress CHAIRS:  Serena Carra and Massimo Santoro
14:30-15:00	Andrea Ballabio, TIGEM, Pozzuoli (NA), Italy Lysosomal signaling controls cell metabolism
15:00-15:15	Roxana Oberkersch, University of Padua, Italy Glutamine metabolism via transaminases regulates angiogenesis through translational control of VEGFR2
15:15-15:30	Patrizia Romani, University of Padua, Italy Regulation of redox metabolism by the metastatic niche
15:30-16:00	Marcus Conrad, Helmholtz Zentrum, Munich, Germany Ferroptosis: a pharmacologically tractable, metabolic form of cell death
16:00-16:15	Break (15')
16:15-16:45	Marco Sandri, University of Padua, Italy Mitochondrial dynamics and nuclear reprogramming in cancer-induced cachexia
16:45-17:00	Giorgia Di Lorenzo, TIGEM, Naples, Italy Transcriptional and post-translational regulation of ER-phagy
17:00-17:30	Human Technopole Lecture Eyal Gottlieb, Technion Israel Institute of Technology, Israel Therapeutic exploitation of metabolic vulnerabilities of cancer
17:30-19:00	Poster session 3

	Tech and Data Integration CHAIRS:  Giulio Pavesi and Beatrice Bodega
14:30-15:00	Francesca Cordero, Dept of Informatics, University of Turin, Italy A unified complex model to study the inter-dependencies among microbiome communities, host health and disease
15:00-15:15	Aurora Savino, University of Turin, Italy Meta-analysis of microdissected breast tumors gene expression databases reveals regulated metabolic pathways in either the stroma or the epithelial compartment
15:15-15:45	Chiara Damiani, Dept of Biotechnologies, University of Milan Bicocca, Italy Multi-omic data integration into computational models unveils the many facets of metabolic regulation
15:45-16:00	Break (15')
16:00-16:15	John Robert Davis, The Francis Crick Institute, London, UK Dissecting the relationship between energy metabolism and cell mechanics
16:15-16:45	Giovanni D’Angelo, EPFL, Lausanne, Switzerland Sphingolipid control of fibroblast heterogeneity revealed by single-cell lipidomics
16:45-17:00	Alessandra Zanon, Eurac Research, Bolzano, Italy Alginate-based 3D culture of human induced pluripotent stem cells reveals an earlier metabolic switching profile during their differentiation to functional dopaminergic neurons
17:00-17:45	Company of Biologists Lecture Christian Metallo, University of California, San Diego, CA, USA Cellular consequences of 1-deoxysphingolipid accumulation
17:45	Prizes for the best posters and short presentations
18:00	Concluding remarks

Prepare your poster as a single A1 page (841 mm by 594 mm; preferably, but not mandatory, in landscape format), just like a traditional "on-site" poster, and save it as a PDF file. Subsequently, upload it through your personal mySIBBM area (where the section Poster Uploads provides additional details for the upload).

Please upload your poster as soon as possible and within 1 June 2021.

Poster Session 1 - Monday, 7 June

P.1 Eylem Akyurek, Legnaro (PD)
Human Brody disease and its animal model cattle pseudomyotonia: from understanding the pathogenetic mechanism to the identification of novel therapeutic approaches

P.2 Mattia Arboit, Padua
A concrete application of Abstract Boolean Networks: how to discover novel reprogramming cocktails thanks to a computational approach

P.3 Valentina Audrito, Turin
The over-expression of the NAD-biosynthetic enzyme NAMPT recapitulates the BRAF Inhibitor resistant phenotype plasticity in melanoma

P.4 Martina Aulitto, Naples
The first archaeal antimicrobial peptide exerting anticancer properties

P.5 Lidia Avalle, Turin
Gene co-expression networks’ hubs as therapeutic targets for basal-like breast cancer

P.6 Anna Martina Battaglia, Catanzaro
Iron administration sensitizes ovarian cancer cells to ferroptosis in a KRAS-independent manner

P.7 Sabrina Battista, Naples
Diet affects stem cell fate by modifying NUMB phosphorylation: role of HMGA1

P.8 Roberta Bortolozzi, Padua
Reprogramming of energy metabolism sustains chemotherapy resistance in medulloblastoma

P.9 Martina Breccia, Milan
Autophagy enhancement as a potential strategy for the treatment of Rett syndrome manifestations

P.10 Sara Bruschini, Catanzaro
Dissecting the tumour immune microenvironment of advanced NSCLC

P.11 Nagaja Capitani, Siena
A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

P.12 Francesca Caprioglio, Milan
The role of RAGE receptor in tumor growth

P.13 Sara Carli, Milan
New insights of neurochemical dysfunction in a Cdkl5 null mouse revealed by in vivo Magnetic Resonance Spectroscopy

P.14 Serena Carra, Modena
Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling: implications for ALS/FTD

P.15 Agata Carreira, Trento
Annotating and overcoming resistance to NAMPT inhibitors in cancer cells

P.16 Alessandro Carrer, Padua
Acetyl-CoA metabolism fosters acinar cell plasticity and supports pancreatic carcinogenesis

P.17 Marta Carro Alvarellos, Padua
Revealing the role of ATAD3B in mitochondrial function: implications for stemness and tumorigenesis

P.18 Francesca Casciaro, Padua
On the epigenetic reprogramming of liver cells induced by differ diets

P.19 Margherita Castellano, Trento
The role of brain transcriptional and epigenetics in the autism spectrum disorder

P.20 Giorgia Centonze, Turin
The p140Cap scaffold protein modulates the mevalonate pathway limiting breast cancer cells aggressiveness

P.21 Marcella Cesana, Naples
TFEB controls human syncytiotrophoblasts differentiation

P.22 Monica Chinellato, Padua
Characterization of class IIa HDACs – MEF2 interaction through X-ray crystallography

P.23 Claudia Cirotti, Rome
Targeting NRF2-mediated chemoresistance in glioblastoma: a novel role for SRC kinase and tyrosine kinase inhibitors

P.24 Marco Corazzari, Novara
Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

P.25 Monica De Luise, Bologna
Loss of Glutaredoxin-2 in cancer leads to altered proteome S-glutathionylation, mitochondrial dysfunction and conversion to more indolent oncocytoma

P.26 Agnese De Mario, Padua
Benzethonium, a novel FDA-approved inhibitor of the Mitochondrial Calcium Uniporter, impinges on breast cancer progression

P.27 Tonia De Simone, Verona
Establishment and characterization of CRISPR/Cas9 miR-34a knockout HeLa cell line

P.28 Michela Denti, Trento
SiRNAs are efficient in switching Tau splicing isoforms in models of 4R tauopathy

Poster Session 2 - Tuesday, 8 June

P.29 Elena Di Nisio, Rome
Study of a new KDM5B protein isoform potentially involved in the tumoral progression of breast cancer

P.30 Linda Diamante, Padua
Stat3 regulates Dnmt3a/b and genomic imprinting in ESCs and early embryos

P.31 Alberto Dinarello, Padua
IL1β inhibition and glucocorticoid stimulation reduce melanoma growth negatively affecting STAT3 activities

P.32 Michael Donadon, Padova
The role of the mevalonate pathway in angiogenesis

P.33 Giulio Donati, Milan
Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma

P.34 Daniela Eletto, Fisciano (SA)
TFF1 is silenced during chronic Helicobacter pylori infection by IFN-gamma

P.35 Fiorella Faienza, Rome
TRAP1 regulation by NO and ROS highlight its potential role as a mitochondrial redox sensor

P.37 Luigi Fattore, Rome
Lipid nanoparticles carrying oncosuppressive miR-199b-5p and miR-204-5p potentiate target therapy for BRAF-mutant metastatic melanoma

P.38 Maria Favia, Bari
Pharmacological glutamine synthetase inhibition as immunometabolic strategy to reduce cancer metastasis in vivo

P.39 Monica Fedele, Naples
Uncovering the downstream signaling landscape responsible for PATZ1-mediated reversion of malignant phenotype in anaplastic thyroid cancer cells: a metabolic perspective

P.40 Fabrizio Fontana, Milan
High mitochondrial mass as a stemness marker and potential therapeutic target in vemurafenib-resistant melanoma

P.41 Angelisa Frasca, Segrare
Neural precursor/stem cell-based therapy for Rett syndrome

P.42 Stefano Fronzoni, Povo TN
Classification strategies and biomarkers for primary myelofibrosis and associated mutation

P.43 Marilisa Galasso, Verona
Catalase expression in leukemia cells is controlled by genetic and epigenetic mechanisms

P.44 Gaia Gherardi, Padua
Mitochondrial metabolism regulates muscle homeostasis in adulthood and ageing

P.45 Sergio Giannattasio, Bari
Yeast as a model to study BRCA2 functions in cellular stress response

P.46 Paolo Grumati, Pozzuoli
Breast cancer cells undergo FAM134B-BiP mediated ER-phagy to mitigate ER-stress

P.47 Francesca Guarino, Catania
Transcriptional regulation of VDAC1 expression by NRF-1 and HIF-1α

P.48 Cise Kizilirmak, Milan
An in vitro model of cell-to-cell communication: mimicking the spatiotemporal dynamics of NF-kB in inflammation

P.49 Claudio Laquatra, Padua
HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

P.50 Michela Libergoli, Trento
Identification of two novel subpopulations of satellite cells with different kinetics of activation

P.51 Valeria Lucchino, Catanzaro
In vitro model for Unverricht-Lundborg disease (ULD) using patient-specific induced pluripotent stem cells

P.52 Vittorio Maglione, Pozzilli
Metabolism of polysialic acid is defective in Huntington’s disease pre-clinical models

P.53 Andrea Magrì, Catania
VDAC1 deletion in yeast affects mitochondrial DNA maintenance and expression  triggering a deep metabolic rewiring towards lipid biosynthesis

P.54 Maria Mangini, Naples
A Raman-based strategy for circulating tumor cell detection

P.55 Giulia Marotta, Milan
Targeting metabolic plasticity of Glioblastoma Tumor Initiating Cells to restore sensitivity to LSD1-directed therapy

P.56 Miriam Martini, Turin
Loss of PI3K-C2G promotes pancreatic cancer cell survival under glutamine-limited conditions via mTOR regulation

Poster Session 3 - Wednesday, 9 June

P.57 Elisabetta Meacci, Florence
Control of skeletal muscle atrophy associated to cancer or corticosteroids by sphingolipids

P.58 Fatima Mentucci, Fisciano (SA)
TFF1 induces aggregation of Helicobacter pylori and slows-down its motility

P.59 Rosanna Mezzapelle, Milan
CXCR4 engagement triggers CD47 reduction and antitumor immunization in a mouse model of mesothelioma

P.60 Elena Montano, Naples
Ink4a/Arf expression marks pancreatic progenitor commitment

P.61 Tommaso Montecchi, Siena
Regulation of T cell responsiveness to adenosine by the adaptor molecule ShcC/Rai

P.62 Alessandra Montecucco, Pavia
Cell metabolism influences the splicing program of SRSF1 transcripts

P.63 Carla Mottini, Rome
Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in COVID-19 cancer patients

P.64 Francesca Orso, Turin
Stroma-derived miR-214 coordinates tumor dissemination

P.65 Alessio Paone, Rome
Riboregulation of human serine hydroxymethyltransferase enzyme activity reveals a novel strategy to shape cell metabolism

P.66 Mauro Passaretti, Milan
Exploiting Live Imaging to Track Nuclei During Myoblast Differentiation and Fusion in wildtype and dystrophic mouse models

P.67 Silvia Piscitelli, Naples
Lin28 molecular complexes regulate Dnmt3a mRNA translation in mouse embryonic stem cells

P.68 Maria Pittalà, Catania
High resolution mass spectrometry analysis of VDAC1 and VDAC3 isoforms in ALS SOD1 model cells reveals specific post translational modifications

P.69 Erica Pranzini, Florence
Mitochondrial serine metabolism mediates 5-fluorouracil resistance in colorectal cancer by fueling nucleotide biosynthesis and supporting DNA damage response

P.70 Lorena Quirico, Turin
Axl-based chimeric aptamers inhibit melanoma and breast cancer tumor progression

P.71 Alessandro Sacco, Italy
Iron overload promotes PD-L1 expression through STAT3/cMyc signaling pathway in non-small cell lung cancer (NSCLC) cells

P.72 Stefania Scalise, Catanzaro
Deciphering the role of SCN1A mutation in different febrile seizure phenotypes using induced pluripotent stem cells-derived neurons

P.73 Luana Scaramuzzino, Catanzaro
Uncovering the function of Ferritin Heavy Chain (FHC) in human embryonic stem cells (ESCs)

P.74 Chiara Soldati, Pozzuoli
Repositioning of drugs to treat Batten disease

P.75 Iolanda Spera, Bari
Glutaminolysis establishes a novel mechanism of metabolic symbiosis between ovarian cancer cells and TAMs

P.76 Sharon Spizzichino, Rome
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

P.77 Chiara Stefani, Verona
HLA-C stability and AIDS progression

P.78 Giovanni Tosi, Padua
The mevalonate enzyme UBIAD1 impairs breast cancer formation and progression by regulating lipid plasma membrane homeostasis

P.79 Daniele Viavattene, Turin
STAT3, IP3R3, and mTOR interplay in the regulation of calcium homeostasis and apoptosis in breast cancer

P.80 Federico Virga, Leuven, Belgium
MiR-210 induction upon macrophage-pathogen interactions supports metabolic reprogramming favouring life-threatening inflammation

P.81 Elisabeth Wyart, Turin
Altered iron compartmentalization drives muscle wasting in cancer cachexia

P.82 Manuela Zangrossi, Padua
EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

P.83 Lorena Zannino, Pavia
Dexamethasone remodels some epigenetic features of heterochromatin domains and nucleolar activity in mouse hepatocytes

P.84 Irene Zorzan, Padua
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human pluripotent stem cells