Società Italiana di Biofisica e Biologia Molecolare

Società Italiana di Biofisica e Biologia Molecolare

SIBBM 2021 • Frontiers in Molecular Biology

SIBBM 2021
Frontiers in Molecular Biology

Online • 7-10 June 2021



All times shown in the programme are

Right now, it is HH:mm (dd mmm 'YY) in Padua.

  • Monday, 7 June · 14:30-19:00

    CHAIR: Sirio Dupont
    14:30-15:00 Welcome Addresses
    Rosario Rizzuto · Rector of the University of Padua
    Valeria Poli · SIBBM President
    Sirio Dupont · Organising Committee of the SIBBM Seminar 2021
    15:00-15:45 AIRC Keynote Lecture
    Karen Vousden, The Francis Crick Institute, London, UK
    Dietary modulation and cancer therapy
    15:45-16:00 Giovannina Barisciano, University of Sannio, Benevento, Italy
    The miR-27a/FOXJ3 axis negatively regulates mitochondrial homeostasis in colorectal cancer cells
    16:00-16:15 Marco Sciacovelli, University of Cambridge, UK
    Nitrogen partitioning between branched-chain amino acids and urea cycle sustains renal cancer progression
    16:15-16:30 Break (15')
    16:30-17:00 Ilaria Elia, Harvard Medical School, Boston, MA, USA
    Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells
      Stem Cells
    CHAIR:  Graziano Martello
    17:00-17:15 Chiara Priami, European Institute of Oncology, Milan, Italy
    P66Shc-dependent asymmetric division of stem cells leads to aging of the mammary gland
    17:15-17:45 EMBL Lecture
    Micheal Teitell, UCLA, Los Angeles, CA, USA
    Mitochondrial Transfer and Cell Fate Transitions
    17:45-19:00 Poster session 1
  • Tuesday, 8 June · 14:30-19:00

    CHAIRS:  Piero Carninci and Alessandra Montecucco
    14:30-15:00 "Riccardo Cortese" Lecture
    Kathryn Wellen, University of Pennsylvania, Philadelphia, PA, USA
    Metabolic compartmentalization and chromatin modification
    15:00-15:15 Vincenzo Sorrentino, Nestlé Research, Lausanne, Switzerland
    Trigonelline is a novel NAD+ precursor with anti-aging muscle benefits across species
    15:15-15:45 John O’Neill, MRC Laboratory of Molecular Biology, University of Cambridge, UK
    The mechanism and function of biological rhythms
    15:45-16:00 Break (15')
    16:00-16:15 Riccardo Betto, University of Padua, Italy
    Stat3 links the metabolic profile and DNA methylation in murine ESCs
    16:15-16:45 Nico Mitro, University of Milan, Italy · sponsored by Giovanni Armenise-Harvard Foundation
    Zc3h10 dependent control of cellular metabolism
    16:45-17:00 Mariella Cuomo, University of Naples “Federico II”, Italy
    DNA methylation dynamics at genes specific level during brain development and in schizophrenia
    17:00-18:00 Science and Society
    Round table: scientific communication and publishing, an update

    Cornelius Gross, Scientific Director EMBL, Monterotondo · MODERATOR

    Sharon Ahmad, Executive Editor Journal of Cell Science
    George Caputa, Editor Nature and Nature Metabolism
    Daniel Klimmeck, Editor EMBO Journal
    Rosalind Mott, Editor Cell Metabolism

    18:00-19:00 Poster session 2
  • Wednesday, 9 June · 14:30-19:00

      Cell Stress
    CHAIRS:  Serena Carra and Massimo Santoro
    14:30-15:00 Andrea Ballabio, TIGEM, Pozzuoli (NA), Italy
    Lysosomal signaling controls cell metabolism
    15:00-15:15 Roxana Oberkersch, University of Padua, Italy
    Glutamine metabolism via transaminases regulates angiogenesis through translational control of VEGFR2
    15:15-15:30 Patrizia Romani, University of Padua, Italy
    Regulation of redox metabolism by the metastatic niche
    15:30-16:00 Marcus Conrad, Helmholtz Zentrum, Munich, Germany
    Ferroptosis: a pharmacologically tractable, metabolic form of cell death
    16:00-16:15 Break (15')
    16:15-16:45 Marco Sandri, University of Padua, Italy
    Mitochondrial dynamics and nuclear reprogramming in cancer-induced cachexia
    16:45-17:00 Giorgia Di Lorenzo, TIGEM, Naples, Italy
    Transcriptional and post-translational regulation of ER-phagy
    17:00-17:30 Human Technopole Lecture
    Eyal Gottlieb, Technion Israel Institute of Technology, Israel
    Therapeutic exploitation of metabolic vulnerabilities of cancer
    17:30-19:00 Poster session 3
  • Thursday, 10 June · 14:30-18:00

      Tech and Data Integration
    CHAIRS:  Giulio Pavesi and Beatrice Bodega
    14:30-15:00 Francesca Cordero, Dept of Informatics, University of Turin, Italy
    A unified complex model to study the inter-dependencies among microbiome communities, host health and disease
    15:00-15:15 Aurora Savino, University of Turin, Italy
    Meta-analysis of microdissected breast tumors gene expression databases reveals regulated metabolic pathways in either the stroma or the epithelial compartment
    15:15-15:45 Chiara Damiani, Dept of Biotechnologies, University of Milan Bicocca, Italy
    Multi-omic data integration into computational models unveils the many facets of metabolic regulation
    15:45-16:00 Break (15')
    16:00-16:15 John Robert Davis, The Francis Crick Institute, London, UK
    Dissecting the relationship between energy metabolism and cell mechanics
    16:15-16:45 Giovanni D’Angelo, EPFL, Lausanne, Switzerland
    Sphingolipid control of fibroblast heterogeneity revealed by single-cell lipidomics
    16:45-17:00 Alessandra Zanon, Eurac Research, Bolzano, Italy
    Alginate-based 3D culture of human induced pluripotent stem cells reveals an earlier metabolic switching profile during their differentiation to functional dopaminergic neurons
    17:00-17:45 Company of Biologists Lecture
    Christian Metallo, University of California, San Diego, CA, USA
    Cellular consequences of 1-deoxysphingolipid accumulation
    17:45 Prizes for the best posters and short presentations
    18:00 Concluding remarks

    Prepare your poster as a single A1 page (841 mm by 594 mm; preferably, but not mandatory, in landscape format), just like a traditional "on-site" poster, and save it as a PDF file. Subsequently, upload it through your personal mySIBBM area (where the section Poster Uploads provides additional details for the upload).

    Please upload your poster as soon as possible and within 1 June 2021.

    Poster Session 1 - Monday, 7 June

    P.1 Eylem Akyurek, Legnaro (PD)
    Human Brody disease and its animal model cattle pseudomyotonia: from understanding the pathogenetic mechanism to the identification of novel therapeutic approaches

    P.2 Mattia Arboit, Padua
    A concrete application of Abstract Boolean Networks: how to discover novel reprogramming cocktails thanks to a computational approach

    P.3 Valentina Audrito, Turin
    The over-expression of the NAD-biosynthetic enzyme NAMPT recapitulates the BRAF Inhibitor resistant phenotype plasticity in melanoma

    P.4 Martina Aulitto, Naples
    The first archaeal antimicrobial peptide exerting anticancer properties

    P.5 Lidia Avalle, Turin
    Gene co-expression networks’ hubs as therapeutic targets for basal-like breast cancer

    P.6 Anna Martina Battaglia, Catanzaro
    Iron administration sensitizes ovarian cancer cells to ferroptosis in a KRAS-independent manner

    P.7 Sabrina Battista, Naples
    Diet affects stem cell fate by modifying NUMB phosphorylation: role of HMGA1

    P.8 Roberta Bortolozzi, Padua
    Reprogramming of energy metabolism sustains chemotherapy resistance in medulloblastoma

    P.9 Martina Breccia, Milan
    Autophagy enhancement as a potential strategy for the treatment of Rett syndrome manifestations

    P.10 Sara Bruschini, Catanzaro
    Dissecting the tumour immune microenvironment of advanced NSCLC

    P.11 Nagaja Capitani, Siena
    A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

    P.12 Francesca Caprioglio, Milan
    The role of RAGE receptor in tumor growth

    P.13 Sara Carli, Milan
    New insights of neurochemical dysfunction in a Cdkl5 null mouse revealed by in vivo Magnetic Resonance Spectroscopy

    P.14 Serena Carra, Modena
    Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling: implications for ALS/FTD

    P.15 Agata Carreira, Trento
    Annotating and overcoming resistance to NAMPT inhibitors in cancer cells

    P.16 Alessandro Carrer, Padua
    Acetyl-CoA metabolism fosters acinar cell plasticity and supports pancreatic carcinogenesis

    P.17 Marta Carro Alvarellos, Padua
    Revealing the role of ATAD3B in mitochondrial function: implications for stemness and tumorigenesis

    P.18 Francesca Casciaro, Padua
    On the epigenetic reprogramming of liver cells induced by differ diets

    P.19 Margherita Castellano, Trento
    The role of brain transcriptional and epigenetics in the autism spectrum disorder

    P.20 Giorgia Centonze, Turin
    The p140Cap scaffold protein modulates the mevalonate pathway limiting breast cancer cells aggressiveness

    P.21 Marcella Cesana, Naples
    TFEB controls human syncytiotrophoblasts differentiation

    P.22 Monica Chinellato, Padua
    Characterization of class IIa HDACs – MEF2 interaction through X-ray crystallography

    P.23 Claudia Cirotti, Rome
    Targeting NRF2-mediated chemoresistance in glioblastoma: a novel role for SRC kinase and tyrosine kinase inhibitors

    P.24 Marco Corazzari, Novara
    Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

    P.25 Monica De Luise, Bologna
    Loss of Glutaredoxin-2 in cancer leads to altered proteome S-glutathionylation, mitochondrial dysfunction and conversion to more indolent oncocytoma

    P.26 Agnese De Mario, Padua
    Benzethonium, a novel FDA-approved inhibitor of the Mitochondrial Calcium Uniporter, impinges on breast cancer progression

    P.27 Tonia De Simone, Verona
    Establishment and characterization of CRISPR/Cas9 miR-34a knockout HeLa cell line

    P.28 Michela Denti, Trento
    SiRNAs are efficient in switching Tau splicing isoforms in models of 4R tauopathy

    Poster Session 2 - Tuesday, 8 June

    P.29 Elena Di Nisio, Rome
    Study of a new KDM5B protein isoform potentially involved in the tumoral progression of breast cancer

    P.30 Linda Diamante, Padua
    Stat3 regulates Dnmt3a/b and genomic imprinting in ESCs and early embryos

    P.31 Alberto Dinarello, Padua
    IL1β inhibition and glucocorticoid stimulation reduce melanoma growth negatively affecting STAT3 activities

    P.32 Michael Donadon, Padova
    The role of the mevalonate pathway in angiogenesis

    P.33 Giulio Donati, Milan
    Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma

    P.34 Daniela Eletto, Fisciano (SA)
    TFF1 is silenced during chronic Helicobacter pylori infection by IFN-gamma

    P.35 Fiorella Faienza, Rome
    TRAP1 regulation by NO and ROS highlight its potential role as a mitochondrial redox sensor

    P.37 Luigi Fattore, Rome
    Lipid nanoparticles carrying oncosuppressive miR-199b-5p and miR-204-5p potentiate target therapy for BRAF-mutant metastatic melanoma

    P.38 Maria Favia, Bari
    Pharmacological glutamine synthetase inhibition as immunometabolic strategy to reduce cancer metastasis in vivo

    P.39 Monica Fedele, Naples
    Uncovering the downstream signaling landscape responsible for PATZ1-mediated reversion of malignant phenotype in anaplastic thyroid cancer cells: a metabolic perspective

    P.40 Fabrizio Fontana, Milan
    High mitochondrial mass as a stemness marker and potential therapeutic target in vemurafenib-resistant melanoma

    P.41 Angelisa Frasca, Segrare
    Neural precursor/stem cell-based therapy for Rett syndrome

    P.42 Stefano Fronzoni, Povo TN
    Classification strategies and biomarkers for primary myelofibrosis and associated mutation

    P.43 Marilisa Galasso, Verona
    Catalase expression in leukemia cells is controlled by genetic and epigenetic mechanisms

    P.44 Gaia Gherardi, Padua
    Mitochondrial metabolism regulates muscle homeostasis in adulthood and ageing

    P.45 Sergio Giannattasio, Bari
    Yeast as a model to study BRCA2 functions in cellular stress response

    P.46 Paolo Grumati, Pozzuoli
    Breast cancer cells undergo FAM134B-BiP mediated ER-phagy to mitigate ER-stress

    P.47 Francesca Guarino, Catania
    Transcriptional regulation of VDAC1 expression by NRF-1 and HIF-1α

    P.48 Cise Kizilirmak, Milan
    An in vitro model of cell-to-cell communication: mimicking the spatiotemporal dynamics of NF-kB in inflammation

    P.49 Claudio Laquatra, Padua
    HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

    P.50 Michela Libergoli, Trento
    Identification of two novel subpopulations of satellite cells with different kinetics of activation

    P.51 Valeria Lucchino, Catanzaro
    In vitro model for Unverricht-Lundborg disease (ULD) using patient-specific induced pluripotent stem cells

    P.52 Vittorio Maglione, Pozzilli
    Metabolism of polysialic acid is defective in Huntington’s disease pre-clinical models

    P.53 Andrea Magrì, Catania
    VDAC1 deletion in yeast affects mitochondrial DNA maintenance and expression  triggering a deep metabolic rewiring towards lipid biosynthesis

    P.54 Maria Mangini, Naples
    A Raman-based strategy for circulating tumor cell detection

    P.55 Giulia Marotta, Milan
    Targeting metabolic plasticity of Glioblastoma Tumor Initiating Cells to restore sensitivity to LSD1-directed therapy

    P.56 Miriam Martini, Turin
    Loss of PI3K-C2G promotes pancreatic cancer cell survival under glutamine-limited conditions via mTOR regulation

    Poster Session 3 - Wednesday, 9 June

    P.57 Elisabetta Meacci, Florence
    Control of skeletal muscle atrophy associated to cancer or corticosteroids by sphingolipids

    P.58 Fatima Mentucci, Fisciano (SA)
    TFF1 induces aggregation of Helicobacter pylori and slows-down its motility

    P.59 Rosanna Mezzapelle, Milan
    CXCR4 engagement triggers CD47 reduction and antitumor immunization in a mouse model of mesothelioma

    P.60 Elena Montano, Naples
    Ink4a/Arf expression marks pancreatic progenitor commitment

    P.61 Tommaso Montecchi, Siena
    Regulation of T cell responsiveness to adenosine by the adaptor molecule ShcC/Rai

    P.62 Alessandra Montecucco, Pavia
    Cell metabolism influences the splicing program of SRSF1 transcripts

    P.63 Carla Mottini, Rome
    Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in COVID-19 cancer patients

    P.64 Francesca Orso, Turin
    Stroma-derived miR-214 coordinates tumor dissemination

    P.65 Alessio Paone, Rome
    Riboregulation of human serine hydroxymethyltransferase enzyme activity reveals a novel strategy to shape cell metabolism

    P.66 Mauro Passaretti, Milan
    Exploiting Live Imaging to Track Nuclei During Myoblast Differentiation and Fusion in wildtype and dystrophic mouse models

    P.67 Silvia Piscitelli, Naples
    Lin28 molecular complexes regulate Dnmt3a mRNA translation in mouse embryonic stem cells

    P.68 Maria Pittalà, Catania
    High resolution mass spectrometry analysis of VDAC1 and VDAC3 isoforms in ALS SOD1 model cells reveals specific post translational modifications

    P.69 Erica Pranzini, Florence
    Mitochondrial serine metabolism mediates 5-fluorouracil resistance in colorectal cancer by fueling nucleotide biosynthesis and supporting DNA damage response

    P.70 Lorena Quirico, Turin
    Axl-based chimeric aptamers inhibit melanoma and breast cancer tumor progression

    P.71 Alessandro Sacco, Italy
    Iron overload promotes PD-L1 expression through STAT3/cMyc signaling pathway in non-small cell lung cancer (NSCLC) cells

    P.72 Stefania Scalise, Catanzaro
    Deciphering the role of SCN1A mutation in different febrile seizure phenotypes using induced pluripotent stem cells-derived neurons

    P.73 Luana Scaramuzzino, Catanzaro
    Uncovering the function of Ferritin Heavy Chain (FHC) in human embryonic stem cells (ESCs)

    P.74 Chiara Soldati, Pozzuoli
    Repositioning of drugs to treat Batten disease

    P.75 Iolanda Spera, Bari
    Glutaminolysis establishes a novel mechanism of metabolic symbiosis between ovarian cancer cells and TAMs

    P.76 Sharon Spizzichino, Rome
    Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

    P.77 Chiara Stefani, Verona
    HLA-C stability and AIDS progression

    P.78 Giovanni Tosi, Padua
    The mevalonate enzyme UBIAD1 impairs breast cancer formation and progression by regulating lipid plasma membrane homeostasis

    P.79 Daniele Viavattene, Turin
    STAT3, IP3R3, and mTOR interplay in the regulation of calcium homeostasis and apoptosis in breast cancer

    P.80 Federico Virga, Leuven, Belgium
    MiR-210 induction upon macrophage-pathogen interactions supports metabolic reprogramming favouring life-threatening inflammation

    P.81 Elisabeth Wyart, Turin
    Altered iron compartmentalization drives muscle wasting in cancer cachexia

    P.82 Manuela Zangrossi, Padua
    EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

    P.83 Lorena Zannino, Pavia
    Dexamethasone remodels some epigenetic features of heterochromatin domains and nucleolar activity in mouse hepatocytes

    P.84 Irene Zorzan, Padua
    The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human pluripotent stem cells